Figure 4.

Hypersensitivity of mice lacking ERO1 to adrenergic blockade. A) Peak left ventricular pressure in anesthetized catheterized mice of wild-type (WT; solid bars), Ero1α (α mut; shaded bars) and compound Ero1α; Ero1β mutant (αβ mut; open bars) genotypes following exposure to the indicated doses of the short-acting β-blocker esmolol. B) Peak positive and negative first derivatives of left ventricular pressure of the mice described in panel A. C) Fraction of surviving animals of each genotype following injection of the indicated dose of esmolol. Data are presented as means ± se; number of animals studied in each group is indicated. *P < 0.05, **P < 0.01.