Table 3.
Three-dimensional microCT analysis of femoral distal metaphysis trabecular structure and midshaft cortical envelope
| Parameter | WT | Hyp | Dmp1−/− | Hyp/Dmp1−/− |
|---|---|---|---|---|
| Trabecular bone | ||||
| Tb.BMD (mgHA/cm3) | 223.0 ± 13.6 | 50.3 ± 2.7* | 37.1 ± 3.3* | 55.3 ± 7.4* |
| BV/TV (%) | 29.9 ± 2.4 | 5.4 ± 0.3* | 4.2 ± 0.4* | 6.3 ± 0.8* |
| Tb.N. (×1−1) | 7.1 ± 0.3 | 3.6 ± 0.1* | 3.6 ± 0.1* | 3.8 ± 0.1* |
| Tb.Th (μm) | 59.0 ± 2.3 | 50.0 ± 1.7 | 57.8 ± 2.7 | 50.6 ± 1.7 |
| Tb.Sp (μm) | 137.0 ± 8.5 | 277.7 ± 4.2* | 291.6 ± 3.7* | 270.3 ± 7.6* |
| Conn.Dens. | 286.4 ± 30.0 | 17.1 ± 3.5* | 11.9 ± 3.3* | 30.3 ± 6.8* |
| SMI | 1.22 ± 0.13 | 2.96 ± 0.08* | 3.24 ± 0.09* | 2.79 ± 0.11* |
| DA | 1.77 ± 0.05 | 2.19 ± 0.13 | 1.66 ± 0.04# | 1.85 ± 0.1 |
| Cortical bone | ||||
| Ct.BMD (mgHA/cm3) | 1054.3 ± 14.4 | 808.8 ± 17.2* | 773.5 ± 10.3* | 794.9 ± 21.2* |
| Ct.Th. (μm) | 136.5 ± 7.3 | 77.3 ± 3.4* | 78.0 ± 2.3* | 80.2 ± 5.7* |
| CSA (mm2) | 2.64 ± 0.16 | 3.22 ± 0.16* | 3.17 ± 0.11* | 3.40 ± 0.14* |
| Ct.Ar. (mm2) | 0.63 ± 0.03 | 0.37 ± 0.02* | 0.43 ± 0.02* | 0.39 ± 0.02* |
| Ma.Ar. (mm2) | 1.93 ± 0.10 | 2.84 ± 0.16* | 2.75 ± 0.10* | 2.94 ± 0.10* |
Values are expressed as means ± se; 5 mice/group. Tb.BMD, trabecular bone mineral density; BV/TV, bone volume/tissue volume; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation; Conn.Dens, connectivity density; SMI, structure model index; DA, degree of anisotropy; Ct.BMD, cortical bone mineral density; Ct.Th, cortical thickness; CSA, cross-sectional area; Ct.Ar, cortical area; Ma.Ar, marrow area.
*
P < 0.05 vs. WT;
#
P < 0.05 vs. Hyp; 1-way ANOVA and post hoc Fisher test.