Table 4.
Expression fold change of the top 32 genes up-regulated in cortical bone as a result of Phex, Dmp1, or both mutations
| Gene | Name | Hyp | Dmp1−/− | Hyp/Dmp1−/− |
|---|---|---|---|---|
| BG083989 | Jak3-like tyrosine-protein | 11.7 | 10.1 | 8.9 |
| Fgf23 | Fibroblast growth factor 23 | 4.4 | 7.1 | 7.2 |
| Fcrls | Fc receptor-like S, scavenger receptor | 6.8 | 4.9 | 4.8 |
| F13a1 | Coagulation factor XIII, A1 subunit | 2.8 | 2.4 | 3.8 |
| Lipg | Lipase, endothelial | 4.0 | 4.1 | 3.6 |
| Ctsw | Cathepsin W | 3.4 | 2.8 | 3.6 |
| Cbr2 | Carbonyl reductase 2 | 4.6 | 3.6 | 3.4 |
| Adamtsl2 | ADAMTS-like 2 | 3.7 | 3.2 | 3.3 |
| DBA2 | Gag related peptide | 4.0 | 3.1 | 3.3 |
| Bzw2 | Basic leucine zipper and W2 domains 2 | 3.2 | 2.8 | 2.9 |
| C530028O21Rik | RIKEN cDNA C530028O21 | 3.4 | 1.7 | 2.8 |
| Csdc2 | Cold shock domain containing C2, RNA binding | 1.8 | 2.3 | 2.6 |
| Epcam | Epithelial cell adhesion molecule | 4.1 | 1.8 | 2.4 |
| Elavl2 | Embryonic lethal, abnormal vision, Drosophila-like 2 | 2.9 | 2.0 | 2.4 |
| Coro2b | Coronin, actin binding protein, 2B | 1.8 | 2.2 | 2.4 |
| Cx3cr1 | Chemokine (C-X3-C) receptor 1 | 2.3 | 2.4 | 2.3 |
| Ihh | Indian hedgehog | 1.6 | 1.4 | 2.3 |
| Stab1 | Stabilin 1 | 2.5 | 2.0 | 2.2 |
| Mup1/Mup2 | Major urinary protein 1/2 | 1.7 | 2.4 | 2.2 |
| Igh | Immunoglobulin heavy chain complex | 1.6 | 2.0 | 2.2 |
| S100b | S100 protein, β polypeptide, neural | 2.3 | 2.2 | 2.1 |
| E2f5 | E2F transcription factor 5 | 1.8 | 2.3 | 2.1 |
| Npy | Neuropeptide Y | 1.7 | 1.9 | 2.1 |
| Gpr84 | G-protein-coupled receptor 84 | 1.7 | 1.8 | 2.1 |
| Fgf1 | Fibroblast growth factor 1 | 2.3 | 1.9 | 2.0 |
| Slc6a9 | Solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 1.5 | 2.2 | 2.0 |
| C1qb | Complement component 1, q subcomponent, β polypeptide | 2.7 | 1.7 | 1.9 |
| Nrxn3 | Neurexin III | 1.4 | 2.1 | 1.9 |
| Add3 | Adducin 3 (γ) | 1.4 | 2.2 | 1.8 |
| Sox10 | SRY-box containing gene 10 | 1.5 | 2.0 | 1.8 |
| EG633640 | Predicted gene, EG633640 | 2.5 | 1.8 | 1.7 |
| 1700049E17Rik1 | RIKEN cDNA 1700049E17 gene 1 | 2.4 | 1.6 | 1.7 |
Values were obtained after clustering analysis on microarray performed in cortical bone of Phex and Dmp1 single-mutant and Phex/Dmp1 double-mutant mice (cluster is represented in Fig. 4A). n = 3 samples/group. Values are expressed as fold change compared to the WT control value. Genes were selected based on a P value threshold of 0.05 and a minimum fold-change absolute value of 2 in ≥1 of the 3 groups.