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. Author manuscript; available in PMC: 2011 Jul 14.
Published in final edited form as: Cancer Invest. 2011 Jan;29(1):62–67. doi: 10.3109/07357907.2010.535057

Figure 2.

Figure 2

Detection of thrombin mRNA using in situ hybridization. We evaluated the presence of thrombin mRNA in () benign prostate (a, c) and prostate cancer (b, d). Antisense probe for thrombin (a, b) and sense probes (c, d) for thrombin. Note localization of thrombin RNA (dark purple color) in epithelial cells (arrows) and stroma (str) as well as intense expression of thrombin mRNA in basal layer (arrowheads). Also note thrombin RNA localization in cancerous prostate tissue, especially within the epithelia (arrows). Additionally note that only counterstain (pink color) is observed in sense strand negative controls (L = lumen, Str = stroma; Bar = 50 µm; insets are at high magnification).