Table 1.
Genes related to bone development are up regulated by DBT.
| Regulated genea | Symbol | Genbank no. | Fold of changeb | ||
|---|---|---|---|---|---|
| DBT | RAS | RA | |||
| Lectin, galactoside-binding, soluble, 9 (Galectin-9) | LGALS9/Gal-9 | AA434102 | 441.76 | 1.60 | 1.77 |
| Small inducible cytokine subfamily A, member 8 | SCYA8/CCL-8 | AI268937 | 184.65 | 2.73 | 2.89 |
| Small inducible cytokine A7 | SCYA7/CCL-7 | AA040170 | 175.02 | 0.33 | 6.96 |
| Small inducible cytokine A2 | SCYA2/CCL-2 | AA425102 | 88.22 | 2.35 | 6.87 |
| Collagen, type XVIII, α1 | COL18α1 | N81029 | 4.49 | 5.03 | 3.99 |
| Matrix metalloproteinase 9 | MMP9 | T72581 | 3.87 | 5.78 | 7.15 |
| Collagen, type X, α1 | COL10α1 | AI828306 | 3.44 | 4.09 | 13.95 |
| Transforming growth factor, β2 | TGFβ2 | AA233738 | 2.60 | 3.40 | 1.77 |
| Insulin-like growth factor 1 | IGF1 | AA456321 | 2.47 | — | — |
| Bone morphogenetic protein 1 | BMP1 | R56774 | 2.29 | 2.88 | 6.66 |
| Epidermal growth factor | EGF | AI480081 | 2.00 | 1.19 | — |
| Integrin, α2 | ITGα2 | AA463257 | 1.87 | 0.75 | 0.85 |
| Msh (Drosophila) homeo box homolog 2 | MSX2 | AA195636 | 1.86 | 1.14 | 0.82 |
| Collagen, type VII, α1 | COL7α1 | AA598507 | 1.86 | 3.49 | 1.76 |
| Bone morphogenetic protein 6 | BMP6 | AA424833 | 1.73 | 2.28 | 1.27 |
| Msh (Drosophila) homeo box homolog 1 | MSX1 | AA464197 | 1.66 | 1.45 | 1.28 |
| Fibroblast growth factor receptor 3 | FGFR3 | AA419620 | 1.65 | 0.97 | 0.82 |
| Cartilage oligomeric matrix protein | COMP | N94385 | 1.64 | 1.30 | 4.82 |
| Transforming growth factor, β1 | TGFβ1 | R36467 | 1.56 | 1.94 | 2.00 |
| Bone morphogenetic protein 8 | BMP8 | AA779480 | 1.41 | 1.73 | 1.30 |
| Bone morphogenetic protein 7 | BMP7 | W73473 | 1.39 | 1.75 | 1.64 |
| Fibroblast growth factor receptor 1 | FGFR1 | R54846 | 1.36 | 1.17 | 1.25 |
| Multiple inositol polyphosphate phosphatase 1 | MINPP1 | AA161161 | 0.29 | 0.47 | 0.57 |
aGenes known to play role in bone development are selected for illustration; bChange of gene expressions as compared to the control (no drug treatment). “—” below detection.