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. Author manuscript; available in PMC: 2012 Jul 14.
Published in final edited form as: J Med Chem. 2011 Jun 8;54(13):4923–4927. doi: 10.1021/jm200304y

Table 1.

Effects of pyridine group substitutions on the activation of SREBP.

graphic file with name nihms302620u1.jpg
Compound R IC50 (μM)a
1 n-Pr 5.6 ± 2.9
4a Et 6.8 ± 3.4
4b H >30
a

All values are mean ± standard deviation, n ≥ 3.