Skip to main content
. Author manuscript; available in PMC: 2012 Jul 14.
Published in final edited form as: J Med Chem. 2011 Jun 8;54(13):4923–4927. doi: 10.1021/jm200304y

Table 3.

Effects of N-substitution on the activation of SREBP.

graphic file with name nihms302620u3.jpg
Compound R IC50 (μM)a
19 H 8.6 ± 2.0
20 Isopropyl 2.8 ± 0.4
21 Benzyl 3.0 ± 0.1
22 Methylcyclopropyl 4.9 ± 3.1
23 Acetyl 7.1 ± 1.5
24 Methansulfonyl 0.7 ± 0.2
25 Thiophenesulfonyl 0.9 ± 0.5
26 Tosyl 2.3 ± 0.0
27 t-Butoxycarbonyl 1.9 ± 0.2
25-hydroxy- cholesterol 0.3 ± 0.0
a

All values are mean ± standard deviation, n ≥ 3.