Table 2. Summary of association results for the two TRAF3IP2 SNPs genotyped in additional replication panels.
The lead SNP rs13210247 and the missense SNP rs33980500 were genotyped in five independent PsV case-control panels (B through F, Supplementary Table 1). The number of cases and controls of each panel is shown in the top column. Nucleotide positions refer to NCBI build 36. Chr., chromosome. A1 denotes the rare allele and A2 is the common allele. Allele frequencies of A1 are shown (AFA1). The combined P value of the meta-analysis is shown for the independent replication panels B to F (Prepl.) as well as for the GWAS panel together with the independent replication panels (panels A through F; Pcomb.).
| Panel A Germany 472cases 1146 controls |
Panel B Germany 681cases 1824 controls |
Panel C CASP 1303 cases 1322 controls |
Panel D Genizon 762 cases 994 controls |
Panel E Michigan 1987 cases 1661 controls |
Panel F Canada 1282 cases 1090 controls |
Panel B – F (replication only) Combined analysis 6015 cases 6891 controls |
Panel A – F (GWAS & replication) Combined analysis 6487 cases 8037 controls |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chr Pos. (bp) |
dbSNP ID | Nearby genes (relative position) |
A1 A2 |
AFA1 Case |
AFA1 Control |
AFA1 Case |
AFA1 Control |
AFA1 Case |
AFA1 Control |
AFA1 Case |
AFA1 Control |
AFA1 Case |
AFA1 Control |
AFA1 Case |
AFA1 Control |
Prepl. | Pcomb. |
| 6 112,029,413 |
rs13210247 | TRAF3IP2 (intronic) | G A |
0.10 | 0.06 | 0.09 | 0.07 | 0.09 | 0.07 | 0.09 | 0.07 | 0.09 | 0.07 | 0.09 | 0.07 | 1.00×10−07 | 2.36×10−10 |
| 6 112,019,955 |
rs33980500 | TRAF3IP2 (missense) | T C |
0.10 | 0.06 | 0.10 | 0.08 | 0.11 | 0.07 | 0.09 | 0.06 | 0.11 | 0.08 | 0.11 | 0.07 | 8.00×10−14 | 1.24×10−16 |