Table 2. Bladder cancer risk associated with GSTM1, GSTT1, and GPX1 polymorphisms.
| UC + SCC | UC | SCC | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR1 | (95% CI) | Cases | Controls | OR1 | (95% CI) | Cases | Controls | OR1 | (95% CI) | |
| GSTM1 | ||||||||||||
| + | 274 | 289 | 1.00 | (Ref.) | 162 | 289 | 1.00 | (Ref.) | 112 | 289 | 1.00 | (Ref.) |
| - | 344 | 332 | 0.94 | (0.74 - 1.18) | 223 | 232 | 0.77 | (0.59 - 1.03) | 121 | 332 | 1.16 | (0.85 - 1.57) |
| GSTT1 | ||||||||||||
| + | 470 | 464 | 1.00 | (Ref.) | 290 | 464 | 1.00 | (Ref.) | 180 | 464 | 1.00 | (Ref.) |
| - | 147 | 156 | 1.09 | (0.83 - 1.42) | 96 | 156 | 0.95 | (0.69 - 1.32) | 51 | 156 | 1.25 | (0.86 - 1.81) |
| GPX1 | ||||||||||||
| CC | 330 | 326 | 1.00 | (Ref.) | 196 | 326 | 1.00 | (Ref.) | 134 | 326 | 1.00 | (Ref.) |
| CT | 236 | 254 | 0.91 | (0.72 - 1.17) | 149 | 254 | 1.01 | (0.74 - 1.36) | 87 | 254 | 0.86 | (0.62 - 1.18) |
| TT | 46 | 38 | 1.02 | (0.64 - 1.64) | 35 | 38 | 1.28 | (0.75 - 2.19) | 11 | 38 | 0.70 | (0.34 - 1.43) |
1
Adjusted for sex, age, region of residence, tobacco smoking, and schistosomiasis.
For GSTM1 and GSTT1 “+” indicates heterozygous or homozygous carriers of the wild-type allele, “-” indicates homozygous carriers of the null allele. Numbers do not sum to to the total samples available because of missing genotype data.