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The effect of ZA on the development of vasculogenic mimicry by LM8 osteosarcoma cells in vitro. The LM8 osteosarcoma cells were seeded on type I collagen gel plaques. They were treated with the vehicle control or 5 μmol/L ZA for 24 hours. The cellular structure was observed under an inverted contrast microscope (A and B, X100) or with a scanning electron microscope (C and D, X2000). E: Zoomed-in area of C.
