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. 2011 Jul 14;7(7):e1002096. doi: 10.1371/journal.pcbi.1002096

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Cole et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — Shown are the eight human BRC repeats used in the computational simulations, as well as the 15 residues of the ligand at the RAD51-RAD51 self-oligomerisation interface. BRCA2 residue numbering is shown in column two, but for simplicity, residues will be labelled 01-15 throughout this paper. The FxxA hotspot is underlined, net charges of each ligand are shown in column three as multiples of the electronic charge and sites of mutations studied here are highlighted in red.

Shown are the eight human BRC repeats used in the computational simulations, as well as the 15 residues of the ligand at the RAD51-RAD51 self-oligomerisation interface. BRCA2 residue numbering is shown in column two, but for simplicity, residues will be labelled 01-15 throughout this paper. The FxxA hotspot is underlined, net charges of each ligand are shown in column three as multiples of the electronic charge and sites of mutations studied here are highlighted in red.