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. 2011 Jul 14;7(7):e1002178. doi: 10.1371/journal.pgen.1002178

Table 3. Allelic combination analysis of the SNPs which are in the same association locus within the HLA region for the ACA and ATA positive subgroups of SSc patients.

SSc Subphenotype	Locus	Haplotype	N (case/control)	Frequency (case/control)	P Value	OR (CI 95%)	SNPs
ACA	HLA-DQB1	TC	761/5172	0.453/0.251	7.807×10⁻⁶¹	2.48 (2.22–2.77)	rs6457617\|rs9275390
		CT	761/5172	0.313/0.490	3.639×10⁻³⁸	0.47 (0.42–0.53)	rs6457617\|rs9275390
		TT	761/5172	0.234/0.259	0.0353	0.87 (0.77–0.99)	rs6457617\|rs9275390
ATA	HLA-DP	CAC	447/5172	0.106/0.013	1.266×10⁻⁷⁶	8.84 (6.72–11.63)	rs987870\|rs3135021\|rs6901221
		TAC	447/5172	0.019/0.012	0.0745	1.55 (0.92–2.60)	rs987870\|rs3135021\|rs6901221
		TGC	447/5172	0.101/0.132	0.00792	0.74 (0.59–0.92)	rs987870\|rs3135021\|rs6901221
		TAA	447/5172	0.265/0.256	0.562	1.05 (0.90–1.23)	rs987870\|rs3135021\|rs6901221
		CGA	447/5172	0.148/0.127	0.0798	1.20 (0.98–1.46)	rs987870\|rs3135021\|rs6901221
		TGA	447/5172	0.361/0.460	2.137×10⁻⁸	0.67 (0.58–0.77)	rs987870\|rs3135021\|rs6901221