Table 2. Finding potential novel Fur targets –a case study.

Locus tag	Name	Description	Operon	Known	COLOMBOS	Meta-analysis	Evidence
b1681	sufD	SufBCD Fe-S cluster scaffold	sufABCDSE	+		+	Fur, OxyR, IHF, lscR
b1683	sufB	SufBCD Fe-S cluster scaffold	sufABCDSE	+	+		Fur, OxyR, IHF, lscR
b2392	mntH	Manganese transport protein	mntH	+	+	+	Fur, MntR
b2673	nrdH	Glutaredoxin-like protein	nrdHIEF	+	+	+	Fur, NrdR
b2674	nrdI	Not annotated	nrdHIEF	+	+	+	Fur, NrdR
b2675	nrdE	Ribonucleoside-Pi reductase 2 α	nrdHIEF	+	+	+	Fur, NrdR
b2676	nrdF	Ribonucleoside- Pi reductase 2 β	nrdHIEF	+	+	+	Fur, NrdR
b4291	fecA	Fe3+ dicitrate transport protein	fecABCDE	+	+		Fur, CRP, PdhR
b0468	ybaN	Inner membrane protein	ybaN		+		Predicted
b0804	ybiX	PKHD-type hydroxylase	ybiX		+		Predicted; Fur dependent expression
b1018	efeO	UPF0409 protein	efeUOB		+		Predicted; functional in related strain
b1452	yncE	Uncharacterized protein	yncE		+	+	Fur dependent expression
b1494	pqqL	Probable zinc protease	pqqL		+		Potential operon yddAB_pqqL
b1495	yddB	Uncharacterized protein	yddAB		+		Predicted
b1705	ydiE	Not annotated	ydiE		+		Predicted; Fur dependent expression
b2211	yojI	ATP-binding ABC transporter	yojI		+
b3070	yqjH	Uncharacterized protein	yqjH		+	+	Predicted
b3337	bfd	Bacterioferritin-associated ferredoxin	bfd-bfr		+		Indirect RhyB regulation
b3410	feoC	Ferrous iron transport protein C	feoABC		+		TU feoABC with feoA known target
b4366	bglJ	Transcriptional activator protein	yjjQ-bglJ		+