Skip to main content
. 2011 Jul 14;6(7):e21968. doi: 10.1371/journal.pone.0021968

Figure 1. CD103 deficiency attenuates intestinal GVHD mediated by donor CD8 T cells.

Figure 1

CD8 T cells primed to A/J alloantigens from either BALB/c-WT (WT) or BALB/c-CD103 KO donors were adoptively transferred into lethally irradiated A/J recipient mice in combination with WT BMC. A. Data shown are survival rates of irradiation control mice (diamonds), recipients of WT BMC plus purified CD8 T cells from either WT (WT CD8, squares, n = 12) or KO donors (KO CD8, triangles, n = 13), and recipients of BMC only (circles, n = 3). These data derive from two separate experiments with similar results. **p-value = 0.003, compared to the survival of hosts receiving WT CD8 T cells (log-rank test). B. H&E sections of the host intestine (upper panel) and spleen (lower panel) taken from recipients of WT or KO CD8 T cells. Arrows indicate apoptotic bodies. C. Mean number of apoptotic bodies per hundred intestinal villi ± SEM in recipients of CD8 T cells from WT donors (WT, closed bar, n = 3) or KO donors (KO, open bar, n = 3). **p<0.01.