Figure 2. CD103 is not required for effective clearance of solid tumor by donor CD8 T cells.

A. Lethally irradiated A/J mice were inoculated with SaI/N fibrosarcoma (H-2^a) plus BALB/c-WT (WT) either alone (BMC only, n = 6) or in combination with purified CD8 T cells from primed WT (n = 8) or BALB/c-CD103 KO donors (n = 8). Data shown are the mean volumes of solid tumor (cm³) measured at the indicated time points ± SEM. N.D. indicates that no tumor was detected. This is a combination of two separate experiments with similar results. Since some experimental mice died early of GVHD, data of 6, 5 or 2 recipient mice of each respective group are shown in last time point. B. Sal/N fibrosarcoma cells (1.0×10⁶) were transferred into BALB.scid mice alone (closed circles; n = 4) or together with primed CD8 T cells (1.0×10⁷) from either WT (triangles; n = 4) or KO donors (open circles; n = 4). Data show mortality of recipient mice. Surviving mice were sacrificed at day 70 after adoptive transfer.