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. 2011 Jul 14;6(7):e21968. doi: 10.1371/journal.pone.0021968

Figure 3. CD103 expression is not required for accumulation of donor CD8 T effectors at the site of tumor growth.

Figure 3

Equal numbers of CD8 T cells from BALB/c-WT (WT, Thy1.1+) and BALB/c-CD103 KO, (KO, Thy1.1+Thy1.2+) donors were adoptively transferred into a group of lethally irradiated A/J mice together with BALB/c-WT BMC plus SaI/N tumor cells. Recipient mice were sacrificed at days 7, 14, 21 and 28. Lymphocytes isolated from the host intestinal epithelium and the tumor were subjected to flow cytometric analyses. A. Representative dot plots of Thy1.2 expression by gated CD8 T cells in the two compartments at the indicated time points. B. Mean ratios ± SEM (n = 5) of WT versus KO CD8 T cells in the intestinal epithelim (IEL, solid circles) and tumor (TIL, open circles). *p<0.05 compared with TIL.