Table 3. Genotype distribution of rs430397 G>A in the fifth intron of the GRP78 gene in HBV-infected individuals with different HBeAg states.
| Variables | Phase In = 89, (%) | Phase IIn = 104, (%) | Phase IIIn = 101, (%) | Phase IVn = 202, (%) |
| Age (mean ± SD, years) | 34.8±9.5 | 42.4±12.6 | 37.9±10.3 | 46.5±14.8 |
| Gender | ||||
| Female | 38 (42.70) | 41 (39.42) | 44 (43.56) | 70 (34.65) |
| Male | 51 (57.30) | 63 (60.58) | 57 (56.44) | 132 (65.35) |
| HBsAg state | + | + | + | + |
| HBeAg state | + | + | − | − |
| Clinical diagnosis | CHC | CHB or LC | IHC | CHB or LC |
| rs430397 | ||||
| Alleles | ||||
| G | 155 (87.08) | 172 (82.69) | 173 (85.64) | 312 (77.23) |
| A | 23 (12.92) | 36 (17.31) | 29 (14.36) | 92 (22.77)* |
| Genotypes | ||||
| GG | 69 (77.53) | 72 (69.23) | 74 (73.27) | 122 (60.40)† |
| AG | 17 (19.10) | 28 (26.92) | 25 (24.75) | 68 (33.66)‡ |
| AA | 3 (3.37) | 4 (3.85) | 2 (1.98) | 12 (5.94) |
CHB, chronic hepatitis B; CHC, chronic hepatitis B virus carrier; HBeAg, hepatitis B e antigen; HBV, hepatitis B virus; IHC, inactive hepatitis B surface antigen carrier; LC, liver cirrhosis.
*Compared with the phase I group, x2 = 7.562 and P = 0.006; and compared with the phase III group, x2 = 5.969 and P = 0.015.
†
Compared with the phase I group, x2 = 8.039 and P = 0.005; and compared with the phase III group, x2 = 4.883 and P = 0.027.
‡
Compared with the phase I group, x2 = 7.131 and P = 0.008.