Figure 4. Evaluation of proton pump inhibitors as transport substrates of OCTs.

Intracellular accumulation of 10 µM [¹⁴C]omeprazole, 10 µM [¹⁴C]pantoprazole, 5 µM lansoprazole, 5 µM rabeprazole, or 5 µM tenatoprazole by vector-transfected control HEK cells (white bars) or OCT-expressing HEK cells (black bars) was measured after 1 or 5 min of incubation. Data are means ± SD of 3 determinations.