. Author manuscript; available in PMC: 2011 Jul 14.

Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2010 Sep 14;88(12):1032–1039. doi: 10.1002/bdra.20717

Table 2.

Adjusted Odd Ratios for the Association of Intake of Folic Acid–Containing Supplements with Craniosynostosis^a

Timing of supplement intake	No. controls	All cases (n = 757)		Sagittal (n = 407)		Metopic (n = 132)		Coronal (n = 128)		Multiple (n = 61)
Timing of supplement intake	No. controls	No. cases	AOR (95% CI)	No. cases	AOR (95% CI)	No. cases	AOR (95% CI)	No. cases	AOR (95% CI)	No. cases	AOR (95% CI)
First trimester	5238	684	Ref.	370	Ref.	117	Ref.	115	Ref.	57	Ref.
Second or third trimester	427	36	0.9 (0.6, 1.3)	16	0.8 (0.5, 1.4)	10	1.4 (0.7, 2.7)	6	0.7 (0.3, 1.8)	1	—
None	281	37	1.2 (0.8, 1.7)	21	1.4 (0.9, 2.2)	5	1.0 (0.4, 2.4)	7	1.1 (0.5, 2.5)	3	1.1 (0.3, 3.7)

Odds ratios were adjusted for mother’s race-ethnicity, education, age, parity, smoking, alcohol intake, body mass index categories, fertility treatments, plurality, and study center.