. Author manuscript; available in PMC: 2011 Jul 14.

Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2010 Sep 14;88(12):1032–1039. doi: 10.1002/bdra.20717

Table 4.

Adjusted Odds Ratios for the Association between Craniosynostosis and Maternal Nutrient Scores, among Women Who Took Folic Acid–Containing Supplements during the First Trimester of Pregnancy^a

	AOR (95% CI)^b
	Sagittal (n = 362)	Metopic (n = 116)	Coronal (n = 113)
One-carbon nutrient score	0.92 (0.87, 0.98)	1.05 (0.94, 1.17)	0.96 (0.86, 1.07)
Oxidative stress nutrient score	0.91 (0.81, 1.03)	1.12 (0.90, 1.40)	0.89 (0.72, 1.10)

Nutrient scores represent the number of relevant nutrients for which intake was greater than the lowest quartile. The one-carbon nutrient score included folate, choline, betaine, methionine, vitamins B₆ and B₁₂, and riboflavin. The oxidative stress nutrient score included beta-carotene and vitamins C and E. The analyses included 5152 controls.

AORs represent the change in risk for a one-unit change in the nutrient score; ORs were adjusted for mother’s race-ethnicity, education, age, parity, smoking, alcohol intake, body mass index, fertility treatments, plurality, study center, and energy intake.

AOR, adjusted odds ratio; CI, confidence interval.