Figure 5. Cytoprotective action of mGluR3 agonists is mediated by reduction of cAMP levels but not by cGMP.

Astrocyte primary cultures were incubated with 1 mM DETA/NO in the presence or absence of 100 µM LY379268 and/or 1 mM db-cAMP or 1 mM 8Br-cGMP for 48 h. Cell viability was assayed by the MTT method. Bars represent the mean ± SEM of 6–8 determinations per group, of one representative experiment of 2 independent ones. *p<0.05 versus control; ∧p<0.05 versus DETA/NO; ###p<0.001 versus DETA/NO+LY379268.