Table 2.
Effects of B. dracunculifolia extract (5–200 mg kg−1) and sulfasalazine (25 mg kg−1) on damage score, changes in colonic weight/length, diarrhea and adherence incidence in TNBS acute colitis
| Group | Damage scorea (0–10) | Colonic weight/lengthb (mg cm−1) | Diarrhoea (%) | Adherence (%) |
|---|---|---|---|---|
| Non-colitic | 0*** | 82.30 ± 3.86** | 0 | 0 |
| TNBS-control | 8.5 (7–9) | 146.99 ± 8.78 | 80.0 | 50.0 |
| B. dracunculifolia | ||||
| 5 mg kg−1 | 6.0 (5–8)* | 127.44 ± 8.06 | 50.0 | 50.0 |
| 10 mg kg−1 | 7.5 (6–8) | 127.82 ± 3.94 | 50.0 | 66.7 |
| 25 mg kg−1 | 7.5 (5–10) | 135.28 ± 6.33 | 66.7 | 66.7 |
| 50 mg kg−1 | 6.5 (5–8)* | 139.10 ± 9.05 | 33.3* | 0* |
| 100 mg kg−1 | 6.5 (4–8) | 131.53 ± 7.34 | 83.3 | 33.3 |
| 200 mg kg−1 | 7.0 (4–8) | 134.62 ± 9.11 | 50.0 | 33.3 |
| Sulfasalazine | 6.0 (2–8)** | 133.58 ± 12.38 | 16.7 | 50.0 |
aScore data are expressed as median (range).
bColonic weight data are expressed as mean ± SEM.
*P < .05; **P < .01; ***P < .001 versus TNBS control group.