Table 4.
Effects of B. dracunculifolia extract (5 and 50 mg kg−1) and sulfasalazine (25 mg kg−1) on damage score, changes in colonic weight/length, diarrhea and adherence incidence in TNBS chronic colitis with relapse
| Group | Damage scorea (0–10) | Colonic weight/lenghtb (mg cm−1) | Diarrhoea (%) | Adherence (%) |
|---|---|---|---|---|
| 1 week | ||||
| Non-colitic | 0*** | 100.57 ± 8.03** | 0* | |
| TNBS-control | 8.0 (7–9) | 276.10 ± 31.17 | 83.3 | |
| B. dracunculifolia 5 mg kg−1 | 2.0 (0–4)* | 140.53 ± 8.61** | 0* | |
| B. dracunculifolia 50 mg kg−1 | 1.0 (0–5)* | 171.00 ± 22.91** | 33.3 | |
| Sulfasalazine 25 mg kg−1 | 3.5 (2–7) | 143.25 ± 20.56** | 0 | |
| 2 week | ||||
| Non-colitic | 0*** | 87.16 ± 4.32** | 0 | |
| TNBS-control | 2.5 (2–3) | 185.40 ± 22.21 | 16.7 | |
| B. dracunculifolia 5 mg kg−1 | 3.0 (0–4) | 117.50 ± 6.45** | 0 | |
| B. dracunculifolia 50 mg kg−1 | 4.0 (2–5) | 141.90 ± 12.02 | 33.3 | |
| Sulfasalazine 25 mg kg−1 | 4.0 (1–6) | 137.95 ± 10.73 | 0 |
aScore data are expressed as median (range).
bColonic weight data are expressed as mean ± SEM.
*P < .05, **P < .01, ***P < .001 versus TNBS control group.