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. Author manuscript; available in PMC: 2012 Jan 21.
Published in final edited form as: Oncogene. 2011 Mar 21;30(29):3207–3221. doi: 10.1038/onc.2011.35

Figure 3. p53 is necessary for FoxO3 mRNA upregulation in response to γ irradiation in thymocytes.

Figure 3

Real time quantitative PCR analysis of FoxO3 (A), p21Cip1 (B), Mdm2 (C), FoxO1 (D), FoxO4 (E), and FoxO6 (F) mRNA levels in p53+/+ and p53−/− thymocytes, 3 hours after γ irradiation (γ IR, 10 Gy). Mean +/− SEM of two independent experiments conducted in triplicate on samples from 3–5 mice per genotype. * p<0.05, ***p<0.001 between p53+/+ and p53−/− thymocytes at a given time point, two-way ANOVA with Bonferroni post-test.