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. Author manuscript; available in PMC: 2012 Jan 21.
Published in final edited form as: Oncogene. 2011 Mar 21;30(29):3207–3221. doi: 10.1038/onc.2011.35

Figure 7. FoxO3 plays a role in p53-dependent apoptosis.

Figure 7

(A) Percent cleaved caspase 3-positive cells in E1A-transformed MEFs (FoxO3+/+p53+/+ (+/+), FoxO3−/−, and p53−/−) in the absence of treatment (−) or in response to Nutlin (N), serum starvation (S), and Nutlin + serum starvation (N+S). Mean +/− SEM of three independent experiments. (B) Real time quantitative PCR analysis of Bim mRNA levels in p53+/+ and p53−/− thymocytes, 3 hours after γ irradiation (γ IR, 10 Gy). Mean +/− SEM of two independent experiments conducted in triplicate on samples from 3–5 mice per genotype. * p<0.05 between p53+/+ and p53−/− thymocytes at a given time point, two-way ANOVA with Bonferroni post-test.