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. Author manuscript; available in PMC: 2012 Jan 21.
Published in final edited form as: Oncogene. 2011 Mar 21;30(29):3207–3221. doi: 10.1038/onc.2011.35

Figure 8. FoxO3 loss does not affect survival in mice that are lacking one or both p53 alleles, but may alter tumor spectrum.

Figure 8

(A). Percent survival of mice with different alleles of FoxO3 in the p53−/− background as a function of time. Kaplan-Meier survival curves with the number of mice indicated for each genotype. p = 0.10, logrank test. (B) Percent survival of mice with different alleles of FoxO3 in the p53+/− background as a function of time. Kaplan-Meier survival curves with the number of mice indicated for each genotype. p = 0.13, logrank test. (C) Tumor types and glomerulonephritis in mice with different alleles of FoxO3 in the p53+/− and p53−/− background. The number of mice is indicated for each genotype. (D) Examples of sarcomas and carcinomas in compound FoxO3/p53 mutant mice. Main panels: 50x. Insets: 630x. i: subcutaneous fibrosarcoma in a FoxO3+/−p53−/− mouse; ii: osteosarcoma in the leg of a FoxO3−/−p53−/− mouse; iii: colon carcinoma in a FoxO3+/−p53−/− mouse; iv: uterine carcinoma in a FoxO3+/−p53+/− mouse; v: breast carcinoma in a FoxO3+/−p53+/− mouse; vi: muscle carcinoma in the arm of a FoxO3+/−p53+/− mouse.