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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: J Invest Dermatol. 2011 Apr 28;131(8):1754–1760. doi: 10.1038/jid.2011.96

Figure 3.

Figure 3

Propanolol, a β-adrenergic antagonist, inhibited curcumin-induced vasodilation, while phentolamine, an α-adrenergic antagoist inhibited curcumin-induced vasoconstriction. Shown are the Early (20 seconds) and Late (60 seconds) diameter changes in response to curcumin in the presence of 10−5M propranolol or 10−5M phentolamine separately (Panel A) or together (Panel B) (Protocol 2). Three concentrations of curcumin were tested in panel B: 10−10M, 10−8M and 10−6M. Responses are shown only for the terminal arteriole in Panel A, and for both arcade and terminal feed arterioles in Panel B. The EC50 and maximal values for both the terminal arteriole and arcading arteriole are given in Table 1. *Phentolamine **Propranolol: individual responses differ from baseline, p<0.05.