Table 1.
Action potentials were recorded from isolated canine atrial or left ventricular Epi or Endo cells at a basic cycle length (BCL) of 1 sec in the absence or presence of 10 μM NS5806. The effects of NS5806 on upstroke velocity (dV/dt), on phase 0 (Ph0), phase 1(Ph1) and phase 2 (Ph2) as well as on action potential duration (ADP) and on resting membrane potential (Erest) of different cell types are summarized.
| Atria | Epi | Endo | |
|---|---|---|---|
| ΔdV/dt | −71±7%, (n=6)*** | −9.8±4.8%, (n=5) * | −4.9±2. 8%, (n=4) * |
| Ph0 Amplitude + NS5806 | 108±4 mV 72±5 mV, (n=6) ** |
124±3 mV 124±3 mV, (n=5), NS |
126±8 mV 125±7, (n=4), NS |
| Notch, Ph1% of Ph2 + NS5806 | - | 28.2±11.1%, (n=5) no Ph2 in 5/5 |
5.5±1.0% 5.1±1.8%, (n=4), NS |
| APD90 + NS5806 | 294±28 ms 187±24 ms, (n=6) *** |
527±46 mS 59±6 mS, (n=5) *** |
535±56 mS 450±28 mS, (n=4), NS |
| Erest + NS5806 | −71.9±0.3 mV −72.6±0.6 mV, (n=6), NS |
−87.1±5 mV −87.4±3 mV, (n=5), NS |
−86.0±6 mV −84.9±6 mV, (n=4), NS |