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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Gene Ther. 2011 Apr 7;18(9):884–890. doi: 10.1038/gt.2011.33

Figure 3. Atoh1 delivery results in restoration of balance after IDPN vestibulotoxicity.

Figure 3

Exposure to IDPN causes a rapid loss of balance function. At 10 days post IDPN feeding, mice showed a significant reduction of rotarod times. A second group of mice was treated with IDPN followed after 10 days with delivery of Ad.gfap.gfp to the inner ear. Before IDPN exposure and on day 10 after exposure (=preop) both IDPN only and the group that were to receive vector were statistically identical. Sixty-two days after vector delivery the atoh1-treated mice performed significantly better than the IDPN only group, showing a significant and sustained recovery of balance as measured by time on the rotarod (P=0.001).