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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Mov Disord. 2011 Apr 11;26(8):1481–1488. doi: 10.1002/mds.23656

Figure 1. Longitudinal results derived from SIENA.

Figure 1

A. Brain Volume Loss(%) is significantly greater in the premanifest Huntington’s disease group when compared to controls. B. Changes in the close-to-onset group drive group differences in Percentage Brain Volume Change. Close-to-onset preHD (Aylward YTO ≤ 6) had greater atrophy than far-from-onset preHD, but this was not significant after covarying for age. Far-from-onset preHD were not significantly different from controls. Error bars represent ± 1 standard error of the mean. Brain Volume Loss (%) equals negative PBVC. PreHD = premanifest Huntington’s disease, FFO = far-from-onset preHD, CTO= close-to-onset preHD.