Table 2.
Physiological Parameters in the FK506 Series
| |
|
Measurement period |
||||||
|---|---|---|---|---|---|---|---|---|
| Variable | Group | Pre-injury | 1 h | 2 h | 3 h | 4 h | 5 h | 6 h |
| MAP (mm Hg) | 1 | 109±2 | 102±4 | 106±2 | 108±4 | 103±4 | 104±2 | 102±4 |
| 2′ | 108±3 | 107±2 | 105±2 | 105±2 | 107±1 | 105±1 | 104±2 | |
| 3′ | 101±6 | 98±5 | 100±4 | 105±3 | 106±4 | 105±5 | 96±5 | |
| 4′ | 103±2 | 101±2 | 101±3 | 106±1 | 99±2 | 97±3 | 97±3 | |
| pH | 1 | 7.42±0.01 | 7.40±0.01 | 7.40±0.01 | 7.39±0.01 | 7.40±0.01 | 7.38±0.01 | 7.38±0.01 |
| 2′ | 7.40±0.01 | 7.39±0.01 | 7.40±0.01 | 7.40±0.01 | 7.40±0.01 | 7.40±0.01 | 7.40±0.01 | |
| 3′ | 7.41±0.01 | 7.40±0.02 | 7.37±0.02 | 7.41±0.01 | 7.39±0.02 | 7.38±0.02 | 7.37±0.02 | |
| 4′ | 7.38±0.01 | 7.40±0.01 | 7.36±0.01 | 7.37±0.01 | 7.38±0.01 | 7.38±0.01 | 7.39±0.02 | |
| Pao2 (mm Hg) | 1 | 90±1 | 92±3 | 90±4 | 91±3 | 91±1 | 90±3 | 90±3 |
| 2′ | 87±2 | 85±2 | 83±2 | 87±4 | 87±4 | 92±3 | 92±2 | |
| 3′ | 92±4 | 89±7 | 90±2 | 91±1 | 91±1 | 86±4 | 89±2 | |
| 4′ | 88±3 | 85±3 | 115±9a | 97±3 | 93±6 | 94±2 | 88±2 | |
| Paco2 (mm Hg) | 1 | 37±1 | 36±1 | 36±1 | 38±1 | 38±1 | 38±1 | 37±1 |
| 2′ | 38±2 | 37±1 | 36±1 | 36±1 | 36±1 | 36±1 | 36±1 | |
| 3′ | 38±1 | 38±1 | 36±1 | 37±1 | 38±1 | 38±1 | 38±1 | |
| 4′ | 39±1 | 37±1 | 36±1 | 38±1 | 36±1 | 36±1 | 38±1 | |
a
Significant difference compared with the values of groups 1, 2’, and 3’ at the same measurement point (p<0.05).
Values are expressed as the mean±standard error of the mean (SEM).
MAP, mean arterial blood pressure; Pao2, arterial oxygen tension; Paco2, arterial carbon dioxide pressure.