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. 2011 Jun;14(3):241–248. doi: 10.1089/rej.2010.1110

FIG. 4.

FIG. 4.

Effect of continuous dexamethasone (DX) treatment on thymic epithelial cell (TEC) gene expression and architecture. (A) Bars showing the mean ± standard deviation (SD) (n = 3) of Wnt-4, Foxn1, lamina associated polypeptide-2α (LAP2α), peroxisome proliferator activator receptor-γ (PPARγ), and adipose differentiation-related protein (ADRP) expression of control (□) and DX-treated (▪) TEC. The levels of Wnt-4, Foxn1, and LAP2α were found to be reduced after repeated in vivo DX injections, whereas PPARγ was unaltered. Additionally, ADRP was found to be elevated in DX-treated samples. Note the scale differences for gene expression. EpCAM1-Ly51 co-staining on thymus sections revealed that in DX-treated samples, the medullar area seems to be smaller compared to control (B, left). ER-TR7 staining showed no significant increase but became more punctuated in DX-treated samples. Images are representative of three independent experiments.

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