Table 2.
Aortic atherosclerotic changes and MDA and serum protein carbonyl levels in the five groups at 8 weeks.
| Group I | Group II | Group III | Group IV | Group V | |
|---|---|---|---|---|---|
| Control | CsA | Cholesterol | Cholesterol + CsA | Cholesterol + CsA + TQ | |
| Atherosclerosis | 0 | 0 | 45.08 ± 11.65* | 38.25 ± 8.74∗† | 18.41 ± 2.38∗‡§ |
| (% of total intimal surface) | |||||
| Intimal area (×103 μm2) | 7.58 ± 1.52 | 4.72 ± 0.752 | 32.38 ± 7.13* | 58.48 ± 15.51∗‡ | 14.82 ± 1.87∗‡§ |
| Medial area (×103 μm2) | 52.31 ± 9.71 | 58.113 ± 8.89 | 64.56 ± 10.88 | 88.32 ± 10.08∗‡ | 82.42 ± 4.71‡ |
| Intima/media ratio | 0.15 ± 0.01 | 0.08 ± 0.02 | 0.52 ± 0.06* | 0.65 ± 0.12∗‡ | 0.18 ± 0.03∗‡§ |
| Aorta MDA (nmol mg−1) | 0.25 ± 0.06 | 0.47 ± 0.26* | 0.53 ± 0.32* | 1.83 ± 0.68∗†‡ | 0.30 ± 0.03†‡§ |
| Serum protein carbonyl content | 1.34 ± 0.25 | 7.88 ± 1.88* | 5.34 ± 1.36* | 15.37 ± 1.29∗†‡ | 9.50 ± 1.74∗†‡§ |
| (nmol ml−1) |
Results are expressed as mean ± SD. Intimal and medial surface areas are expressed as ×103 μm2.
*P < .05, Group I versus other groups.
† P < .05, Group II versus Groups III, IV and V.
‡ P < .05, Group III versus Groups IV and V.
§ P < .05, Group IV versus Group V.