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EPZ and its dependence on TM surface concentration (1000, 500, 100, and 80 fmol/cm2), for a wall shear rate of 500 s−1, TFlength of 2 mm, and [TF] of 0.8 fmol/cm2. Simulations were run to 60 min. The EPZ is delineated by a contour line, wherein at any point within the space, the thrombin concentration was within 95% of the peak level.
