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Role of calcium-dye affinity. (a and b) Comparison of optical Caopt traces simulated using a HA (solid line) and LA (dashed line) calcium-sensitive dye taken from the central site in Fig. 1 for rapid pacing (a) and VF (b). (c) Bar graphs of maximum MI scores, averaged across all nine recording sites during VF and rapid pacing, showing optical data for the LA calcium dye with the electrical data from Fig. 4b.
