Dependence upon difference in penetration depths for VF (left) and rapid pacing (right). (a and b) Comparison of Vopt (a) and Caopt (b) traces obtained upon variation of the penetration depth (δ) of each signal by , 1.5 × (high), and 0.5 × (low), and by , 1.5 × (high), and 0.5 × (low). (c) Variation in maximum MI between the optical (Vopt/Caopt) signals as the relative penetration depth (δ) of each signal is varied for all combinations of high, default, and low penetration depths.