Table 1.
Effect of silibinin on body and liver weight.
| Parameters | BW (g) | WG (g) | LW (g) | LIa (%) |
|---|---|---|---|---|
| Control | 559 ± 18 | 469 ± 6 | 14.2 ± 0.5 | 2.5 ± 0.1 |
| NASH | 526 ± 15 | 433 ± 17 | 16.7 ± 0.6* | 3.2 ± 0.1* |
| Silibinin | 510 ± 12 | 432 ± 11 | 13.4 ± 0.8** | 2.6 ± 0.1** |
| ANOVA | 0.065 | 0.085 | 0.0184 | 0.0071 |
Measurements were obtained from rats on the day of sacrifice, after 12 weeks of standard diet (control) or high-fat diet alone (NASH), or supplemented with silibinin–phosphatidylcholine complex (Silibinin), at a dose of 200 mg kg−1 as silibinin, during the last 5 weeks. Values are expressed as means ± SE of six rats for control and NASH groups and of eight rats for Silibinin group.
aLI, LW/BW × 100.
*P < .05 versus control group. **P < .05 versus NASH group.