Table 3.
Effect of silibinin on liver histology scoring for macrovesicular steatosis and inflammatory cells infiltration.
| Groups | N | Steatosisa | Inflammationb | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 | ||
| Control | 6 | 5 | 1 | 0 | 0 | 5 | 0 | 1 | 0 |
| NASH | 6 | 0 | 0 | 1 | 5 | 0 | 0 | 3 | 3 |
| Silibinin | 8 | 3 | 2 | 1 | 2 | 2 | 1 | 4 | 1 |
| Chi-square | P < .05 | P < .05 | |||||||
Histological scoring for steatosis and inflammation from rats fed a standard diet for 12 weeks (control) or a high-fat diet alone (NASH), or supplemented with silibinin-phosphatidylcholine complex (Silibinin), at a dose of 200 mg kg−1 as silibinin, during the last 5 weeks. The P values for the Chi square test are given and differences are significant among all groups for both parameters.
aMacrovesicular steatosis: grade 0 absent; grade 1 < 33%; grade 2: 33–66%; grade 3: >66%. bInflammation: 0 normal; 1 mild; 2 moderate; 3 severe.