Table 2.

Organ involvement and functional measures among 2300 SSc patients evaluated from 1990–2009.

Frequency of Dichotmized Medsger Severity Scores (%)
	Age of onset < 65 years		Age of onset ≥ 65 years
	No	Yes	No	Yes	p-value
Cardiac Disease*	1386 (77)	425 (23)	113 (63)	67 (37)	<0.001
Digital Ischemia§	893 (43)	1180 (57)	133 (62)	80 (37)	<0.001
GI Involvement†	206 (19)	857 (81)	31 (34)	59 (66)	0.001
Renal Involvement**	1536 (84)	302 (16)	127 (69)	57 (31)	<0.001
Muscle Weakness††	1384 (77)	418 (23)	118 (68)	56 (32)	0.008

Maximum Scleroderma Health Assessment Questionnaire Score, mean ± SD (N)
	Age of onset < 65 years	Age of onset ≥ 65 years	p-value
General disease	1.58 ± 2.70 (1478)	1.50 ± 0.91 (138)	0.742
Intestine	0.95 ± 0.97 (1475)	0.79 ± 0.90 (136)	0.059
Breathing	1.00 ± 0.98 (1482)	1.07 ± 1.01 (135)	0.435
Raynaud phenomenon	1.28 ± 1.04 (1461)	0.94 ± 0.92 (131)	<0.001
Digital ulcers	0.97 ± 1.22 (1463)	0.66 ± 0.97 (129)	0.005

Maximum General Health Assessment Questionnaire Disability Index, mean ± SD (N)
Score	1.11 ± 0.8 (1847)	1.23 ± 0.8 (185)	0.055

^*Cardiac MSS ≥1 which includes clinically significant conduction or structural cardiac abnormalities or overt heart failure

^§Raynaud MSS ≥2 which includes digital pitting, ulcers or gangrene and indicates the presence of tissue damage

^†GI MSS ≥ 2 which includes any GI involvement beyond gastroesophageal reflux requiring routine treatment

^**Renal MSS ≥1 which includes a creatinine ≥1.3 mg/dL or ≥2+ protein on urine dipstick

^††Muscle MSS ≥1 which equates to motor strength <5/5 in upper or lower extremity proximal muscle groups