Table 3.

Cardiopulmonary diagnostic testing among 2300 SSc patients evaluated from 1990–2009.

	Age of onset < 65 years	Age of onset > 65 years	p-value
Pulmonary Function Tests
No obstruction: FEV1/FVC ≥ 70%	1445/1808 (80%)	123/179 (69%)	0.001
Mean ± SD* FEV1/FVC	0.79 ± 0.06	0.79 ± 0.06	0.109
Mean ± SD minimum percent predicted FVC	69 ± 21	76 ± 22	0.001
Mean ± SD minimum percent predicted TLC	78 ± 21	85 ± 26	0.001
Mean ± SD minimum percent predicted DLCO	62 ± 26	65 ± 29	0.176
Obstruction: FEV1/FVC < 70%	363/1808 (20%)	56/179 (31%)	0.001
Mean ± SD FEV1/FVC	0.62 ± 0.12	0.61 ± 0.09	0.654
Mean ± SD minimum percent predicted FVC	70 ± 21	74 ± 17	0.129
Mean ± SD minimum percent predicted TLC	83 ± 21	93 ± 26	0.002
Mean ± SD minimum percent predicted DLCO	58 ± 23	54 ± 25	0.211
Echocardiography, mean ± SD
Minimum ejection fraction (n=1736)	56 ± 9	55 ± 10	0.133
Maximum RVSP, mmHg (n=1428)	44 ± 21	49 ± 20	0.007
Right heart cardiac catheterization measures
PA pressure ≥25mmHg and PCWP ≤15 mmHg	151 (7%)*	19 (9%)*	0.413
PA pressure ≥25mmHg and PCWP >15 mmHg	35 (2%)*	6 (3%)*	0.248

^*260 right heart catheterizations were completed among patients with younger SSc onset (< 65 years); and 35 right heart catheterizations were completed among patients with late-age SSc onset (≥ 65 years). The percentages represent number of catheterizations meeting criteria out of total number of younger SSc onset patients (n=2084) or late-age SSc onset patients (n=216).