Table 4.

Risk of organ involvement in scleroderma^◇

Outcome	Age-onset† modeled as dichotomous variable OR (95% CI)	Age-onset† modeled as continuous variable†† OR (95% CI)
Pulmonary hypertension (right heart catheterization) n=2300
Unadjusted	1.23 (0.75, 2.03)	1.09 (0.98, 1.22)
Adjusted*	1.76 (1.00, 3.12)	1.34 (1.17, 1.54)
Pulmonary hypertension (echocardiogram or right heart catheterization) n=2300
Unadjusted	1.89 (1.42, 2.52)	1.25 (1.17, 1.33)
Adjusted*	3.28 (2.34, 4.60)	1.66 (1.52, 1.81)
Restrictive lung disease (FVC <70%): among non-obstructed n=1568
Unadjusted	0.69 (0.47, 1.00)	0.95 (0.88, 1.02)
Adjusted**	0.80 (0.54, 1.19)	1.01 (0.93, 1.09)
Cardiac disease n=1991
Unadjusted	1.93 (1.40, 2.66)	1.30 (1.21, 1.40)
Adjusted**	2.69 (1.92, 3.78)	1.60 (1.46, 1.75)
Muscle weakness n=1976
Unadjusted	1.57 (1.12, 2.20)	1.09 (1.01, 1.17)
Adjusted§	1.85 (1.30, 2.64)	1.14 (1.05, 1.23)
Digital ischemia n=2286
Unadjusted	0.45 (0.34, 0.61)	0.75 (0.71, 0.80)
Adjusted§§	0.64 (0.47, 0.86)	0.82 (0.76, 0.87)
Severe gastrointestinal involvement n=1153
Unadjusted	0.46 (0.29, 0.72)	0.92 (0.83, 1.02)
Adjusted§	0.80 (0.49, 1.30)	1.11 (0.99, 1.25)
Renal impairment n=2022
Unadjusted	2.28 (1.63, 3.19)	1.27 (1.17, 1.38)
Adjusted§	2.83 (1.98, 4.04)	1.41 (1.28, 1.55)

^◇Age modeled as both dichotomous and continuous variables in logistic regression

^†Late-onset defined as first non-Raynaud's scleroderma symptom ≥ 65 years of age

^††Age-onset per ten years

^*Adjusted for race, sex, subtype, disease duration, FVC

^**Adjusted for race, sex, subtype, disease duration, smoking status

^§Adjusted for race, sex, subtype, disease duration

^§§Adjusted for race, sex, subtype, disease duration, smoking status