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Molecular model of the interaction between an anti-DNA antibody and DNA. According to the proposed model, the HC-CDR1 and HC-CDR2 extend into the major groove of DNA whereas the HC-CDR3 straddles one of the phosphate backbones. The loop of the HC-FWR3 is positioned such that it contributes to contacts within the minor groove. The LC binds primarily through CDR1, which reaches into the minor groove. Adapted from reference 64.
