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A cartoon model of UVRAG-Rubicon in autophagosome and endosome maturation. UVRAG (the General) acts as a strong activator for both PI3KC3 and HOPS, but it is only active if it escapes the sequestration of Rubicon (by crossing the Rubicon river). Rab7 (the boat) allows UVRAG to sail through the Rubicon by competing for its binding with Rubicon, leading to PI3KC3 and HOPS activation and lysosomal degradation.
