Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Jul 11;6(7):e22031. doi: 10.1371/journal.pone.0022031

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Vande Velde et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

MitoEGFP (green) expressed in the sciatic nerves in control (A), asymptomatic SOD1^G85R 7 months (B and C), SOD1^G85R 8 months (D and E), and SOD1^G37R early symptomatic (F and G) labeled with Fluoromyelin red (red). Round and evenly distributed mitochondria are seen in both SOD1^G85R (symptomatic stage) and SOD1^G37R (early symptomatic stage). Mitochondria `pile-up or clusters are also seen in the proximal side of SLIs (arrows) in the SOD1^G37R axons. Arrowheads indicate “strings” of mitochondria. Arrows indicate SLIs (H) Schematic indicating proximal and distal locations of SLIs. Mitochondrial area (I), length (J), aspect ratio (K), and density (L) were evaluated in motor axons of the sciatic nerves of and mutant SOD1 animals of various ages and age-matched MitoEGFP control animals, as described in detail in the Materials and Methods. Statistics are indicated: *, p<0.05; **, p<0.005; ***, p<0.0005.

Inline graphic — MitoEGFP (green) expressed in the sciatic nerves in control (A), asymptomatic SOD1^G85R 7 months (B and C), SOD1^G85R 8 months (D and E), and SOD1^G37R early symptomatic (F and G) labeled with Fluoromyelin red (red). Round and evenly distributed mitochondria are seen in both SOD1^G85R (symptomatic stage) and SOD1^G37R (early symptomatic stage). Mitochondria `pile-up or clusters are also seen in the proximal side of SLIs (arrows) in the SOD1^G37R axons. Arrowheads indicate “strings” of mitochondria. Arrows indicate SLIs (H) Schematic indicating proximal and distal locations of SLIs. Mitochondrial area (I), length (J), aspect ratio (K), and density (L) were evaluated in motor axons of the sciatic nerves of and mutant SOD1 animals of various ages and age-matched MitoEGFP control animals, as described in detail in the Materials and Methods. Statistics are indicated: *, p<0.05; **, p<0.005; ***, p<0.0005.