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. 2011 Jul 11;6(7):e21977. doi: 10.1371/journal.pone.0021977

Figure 4. Major signaling network 1 associated with the proteins differentially expressed in MB-231-Br compared with MB-231-Pa cells identified by the Ingenuity pathway analysis.

Figure 4

The network consists of 35 nodes and includes 11 out of 12 differentially expressed proteins (shaded green). Note the interactions of NASP, RPS10, HSPA8, and HSPA1B with TRAF6 (TNF receptor-associated factor 6), a key factor acting upon the TNFα/TGFβ signaling axis, as well as the involvement of NFκB-, HSP-70-, TP53-, and IFNγ-associated pathways.