Table 2. Major signal transduction pathways involved with signaling networks associated with three breast carcinoma brain metastasis signatures.

	Major Pathways Involved
Major Network	HSP-70	NFKB	TP53	TNFα/TGFβ	MAPK	Akt	IFNα/γ
MB-231-Br Network 1	+	+	+	+			+
MB-231-Br Network 2	+	+		+			+
435-Br1 Network 1	+	+		+	+
435-Br1 Network 2			+	+
17-Gene Classifier Network 1		+		+	+	+	+
17-Gene Classifier Network 2				+