Figure 2.

Schematic of RASSF1A. The SH3 binding domain of RASSF1A has the sequence PAGP that is conserved in mouse and human forms of RA SSF1A and found as PQDP in RA SSF5A. The ATM (Ataxia telangiectasia mutated) phosphorylation site is underlined with surrounding residues shown. ATM is a serine/threonine protein kinase that is a DNA damage sensor activated upon double strand breaks (DSBs), apoptosis or the addition of genotoxic stresses such as ultraviolet A light (UVA). The binding sites for several RA SSF1A effector proteins are shown. The Ras association domain (RA) may potentially associate with the Ras family of oncogenes. The SARAH domain modulates heterotypic associations with the sterile-20 like kinases, MST1 and MST2. Approximate positions of exons and amino acids are also indicated as well as the identification of several polymorphisms to RASSF1A. Adapted from El-Kalla et al. (2010).⁴⁹ See text for details on the other functional domains.