TABLE 1.
LUNG FUNCTION MEASUREMENTS OF 10 INBRED MOUSE STRAINS
| Strain |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | AKR/J | BTBR/T+ tf/J | CAST/EiJ | CZECHII/EiJ | DBA/2J | KK/HIJ | MOLF/EiJ | NOD/ShiLtJ | NZW/LacJ | WSB/EiJ |
| BW, g | 31 (1.2) | 32 (0.6) | 13 (0.3) | 12.0 (0.9) | 24 (0.8) | 35 (1.3) | 13 (0.2) | 22 (0.6) | 27 (0.8) | 14 (0.03) |
| Age, d | 96 (0.4) | 84 (0.2) | 96 (0.2) | 94 (0.6) | 93 (0.2) | 84 (0.2) | 93 (2.3) | 91 (0.2) | 86 (0.2) | 89 (0.9) |
| Number | 8 | 8 | 6 | 12 | 8 | 7 | 14 | 8 | 8 | 11 |
| Lung volume | ||||||||||
| TLC, μl | 1,176 (32) | 1,409 (26) | 751 (9) | 679 (9) | 1,054 (17) | 1,304 (29) | 855 (14) | 1,012 (25) | 1,218 (26) | 744 (27) |
| TLC/BW, μl/g | 38.7 (1.4) | 44.4 (1.5) | 57.7 (0.8) | 56.6 (0.9) | 43.8 (1.7) | 37.5 (1.4) | 64.8 (1.2) | 46.4 (1.6) | 44.5 (0.6) | 51.5 (1.7) |
| FRC, μl | 304 (2) | 343 (9) | 272 (3) | 272 (4) | 289 (11) | 304 (9) | 281 (4) | 303 (6) | 310 (5) | 273 (6) |
| FRC/TLC | 0.26 (0.01) | 0.24 (0.01) | 0.36 (0.01) | 0.40 (0.01) | 0.27 (0.01) | 0.23 (0.01) | 0.33 (0.01) | 0.30 (0.01) | 0.25 (0.01) | 0.37 (0.01) |
| Vd, μl | 231 (4) | 251 (3) | 179 (5) | 177 (4) | 232 (3) | 246 (2) | 217 (5) | 222 (2) | 250 (4) | 201 (4) |
| Vd/TLC | 0.20 (0.01) | 0.18 (0.01) | 0.24 (0.01) | 0.26 (0.01) | 0.22 (0.01) | 0.19 (0.01) | 0.25 (0.01) | 0.22 (0.01) | 0.21 (0.01) | 0.27 (0.01) |
| Compliance | ||||||||||
| Cl, μl/cm H2O | 58.3 (2.8) | 82.1 (3.0) | 31.6 (2.2) | 25.2 (0.9) | 61.1 (1.5) | 61.2 (2.7) | 34.8 (1.9) | 61.5 (3.1) | 92.4 (7.0) | 30.2 (1.4) |
| Cl/TLC, 1/cm H2O | 49.8 (2.7) | 58.2 (1.7) | 46.1 (3.2) | 36.3 (1.1) | 58.0 (1.3) | 47.0 (1.9) | 40.7 (2.0) | 60.7 (2.4) | 75.9 (5.5) | 40.8 (1.6) |
| Cdyn, μl/cm H2O | 41.1 (1.7) | 57.7 (2.4) | 22.6 (1.5) | 19.9 (0.8) | 38.4 (0.8) | 46.5 (1.3) | 24.6 (0.6) | 43.5 (1.9) | 58.9 (3.4) | 21.1 (0.6) |
| Diffusion capacity | ||||||||||
| Dco, μmol/min/hPa | 13.9 (0.4) | 17.4 (0.3) | 4.7 (0.03) | 3.0 (0.1) | 9.5 (0.3) | 11.4 (0.7) | 5.6 (0.4) | 10.3 (0.4) | 11.4 (0.5) | 5.1 (0.4) |
| Dco/Va, μmol/min/hPa/ml | 12.4 (0.03) | 13.1 (0.2) | 6.4 (0.04) | 4.7 (0.2) | 10.1 (0.1) | 9.3 (0.3) | 7.4 (0.3) | 11.2 (0.2) | 10.4 (0.2) | 7.5 (0.3) |
Definition of abbreviations: BW = body weight; Cdyn = dynamic lung compliance; Cl = static lung compliance; Dco = diffusion capacity; FRC = functional residual capacity; TLC = total lung capacity; Va = alveolar volume; Vd = dead space volume.
Values represent means (SE).