TABLE 5.
MULTIPLE LOGISTIC REGRESSION MODEL FOR BERYLLIUM SENSITIZATION, CONSIDERING HLA-DPB1 E69 GENOTYPE
| Independent Variable | Regression Coefficient | Standard Error | P Value | OR (95% CI) |
|---|---|---|---|---|
| Intercept | −3.72 | 0.48 | <0.001 | |
| HLA-DPB1 E69 genotype | ||||
| HLA-DPB1 E69− | Ref. | |||
| Single HLA-DPB1*02 allele (with E69− allele) | 2.48 | 0.53 | <0.001 | 12.01 (4.28–33.71) |
| Single HLA-DPB1 E69+ non-*02 allele (with E69− allele) | 3.39 | 0.54 | <0.001 | 29.54 (10.33–84.53) |
| E69 homozygote (*02 plus non-*02 E69+) | 4.01 | 0.68 | <0.001 | 55.68 (14.80–209.40) |
| Worked less than 5 yr at RFETS | 1.04 | 0.39 | 0.008 | 2.83 (1.31–6.13) |
Definition of abbreviations: CI = confidence interval; E69 = glutamic acid at position 69; OR = odds ratio; Ref. = reference group; RFETS = Rocky Flats Environmental Technology Site.