TABLE 6.
MULTIPLE LOGISTIC REGRESSION MODEL FOR CHRONIC BERYLLIUM DISEASE, CONSIDERING HLA-DPB1 E69 GENOTYPE AND EXPOSURE
| Independent Variable | Regression Coefficient | Standard Error | P Value | OR (95% CI) |
|---|---|---|---|---|
| Intercept | −2.92 | 0.34 | <0.001 | |
| HLA-DPB1 E69− genotype | ||||
| HLA-DPB1 E69− | Ref. | |||
| Single HLA-DPB1*02 allele (with E69− allele) | 1.24 | 0.45 | 0.006 | 3.46 (1.42–8.43) |
| Single HLA-DPB1 E69+ non-*02 allele (with E69− allele) | 2.48 | 0.43 | <0.001 | 11.97 (5.12–28.00) |
| E69 homozygote (*02 plus non-*02 E69+) | 3.11 | 0.60 | <0.001 | 22.54 (7.00–72.62) |
| Per unit increase in lifetime weighted average Be exposure, μg/m3 | 0.80 | 0.31 | 0.010 | 2.22 (1.21–4.07) |
Definition of abbreviations: CI = confidence interval; E69 = glutamic acid at position 69; OR = odds ratio; Ref. = reference group.